The aim of this study was to assess treatment outcomes of private-private mix Tuberculosis (TB) control program in South-Eastern Nigeria. A retrospective cohort study design was used to analyze secondary data set (2007-2010) of patients accessing TB Directly Observed Short course treatment in two private health facilities Hospitals 1 and 2 in South-Eastern Nigeria. Gender of patients were male: female 48%(34 patients): 52%(37 patients) and 60%(29 patients): 40%(19 patients) in Hospitals 1 and 2 respectively. Treatment outcomes were compared against targets set by WHO which are 85% cure rate, 5% treatment completed, 1-2% treatment failure, 2-3% deaths, 5% lost, and 5% transfer out. Gender of patients were male: female 48%(34 patients): 52%(37 patients) and 60%(29 patients): 40%(19 patients) in Hospitals 1 and 2 respectively. In 2007 health facilities adjudged as effective were, Hospitals 1and 2 using the indicator of treatment failure rate; Hospitals 1 and 2 using the indicator of death rate; Hospitals 1 and 2 using the indicator of transfer out rate. In 2008: Hospitals 1 and 2 using the indicator of failure rate; Hospital 1using the indicator of death rate; Hospitals 1 and 2 using the indicator of transfer out rate. In 2009, effective health facilities was only Hospital 1 using the indicator of cure rate; Hospitals 1 and 2 using the indicator of treatment failure rate; Hospitals 1 and 2 using the indicator of death rate; Hospitals 1 and 2 using the indicator of transfer out rate; Hospital 2 using the indicator of Treatment completion rate. In 2010: only Hospital 1 using the indicator of cure rate; Hospitals 1 and 2 using the indicator of treatment failure rate; Hospitals 1 and 2 using the indicator of death rate; only Hospital 1 using the indicator of transfer out rate; Hospital 2 using the indicator of treatment completion rate. In conclusion, Hospital 1 was more effective than Hospital 2 facility over the four years time period.