Treatment of alloxan-induced diabetic rats with metformin or glitazones is associated with amelioration of hyperglycaemia and neuroprotection
Neurobehavioural and cognitive impairments are reportedly associated with both types of
diabetes mellitus; and the structural and molecular aberrations in support of these are
emerging. In the present study, we report the effects of induced diabetes and its treatment
with or without oral hypoglycaemic drugs on the morphology and oxidative stress status of
the prefrontal cortex. Hyperglycaemia was induced in fasted Wistar rats with alloxan (150
mg/kg body weight). Hyperglycaemic rats were treated with or without oral hypoglycaemic …
diabetes mellitus; and the structural and molecular aberrations in support of these are
emerging. In the present study, we report the effects of induced diabetes and its treatment
with or without oral hypoglycaemic drugs on the morphology and oxidative stress status of
the prefrontal cortex. Hyperglycaemia was induced in fasted Wistar rats with alloxan (150
mg/kg body weight). Hyperglycaemic rats were treated with or without oral hypoglycaemic …
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