Tricarbonylrhenium (I) complexes of phosphine-derivatized amines, amino acids and a model peptide: structures, solution behavior and cytotoxicity
J Zhang, JJ Vittal, W Henderson, JR Wheaton… - Journal of …, 2002 - Elsevier
Modified Mannich reactions of amines, amino acids and a model peptide with Ph2PH and
CH2O gave bis (diphenylphosphinomethyl) amines (Ph2PCH2) 2NR [R= Ph (1),
CH2CH2OH (2), CH2COOCH2Ph (3), CH2CONHCH2COOCH2Ph (4), CH2COOH (5)] and
(Ph2PCH2) 2NCH2CH2N (CH2PPh2) 2 (6). Reaction with [ReBr3 (CO) 3] 2− under mild
conditions led to [ReBr (CO) 3]{(Ph2PCH2) 2NR}[R= Ph (7), CH2CH2OH (8),
CH2COOCH2Ph (9), CH2CONHCH2COOCH2Ph (10), CH2COOH (11)] and [ReBr (CO) 3 …
CH2O gave bis (diphenylphosphinomethyl) amines (Ph2PCH2) 2NR [R= Ph (1),
CH2CH2OH (2), CH2COOCH2Ph (3), CH2CONHCH2COOCH2Ph (4), CH2COOH (5)] and
(Ph2PCH2) 2NCH2CH2N (CH2PPh2) 2 (6). Reaction with [ReBr3 (CO) 3] 2− under mild
conditions led to [ReBr (CO) 3]{(Ph2PCH2) 2NR}[R= Ph (7), CH2CH2OH (8),
CH2COOCH2Ph (9), CH2CONHCH2COOCH2Ph (10), CH2COOH (11)] and [ReBr (CO) 3 …
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