Trophoblast debris extruded from preeclamptic placentae activates endothelial cells: a mechanism by which the placenta communicates with the maternal …
F Shen, J Wei, S Snowise, J DeSousa, P Stone, C Viall… - Placenta, 2014 - Elsevier
Introduction Preeclampsia is characterized by maternal endothelial dysfunction. While the
mechanisms leading to preeclampsia are unclear, a factor (s) from the placenta is
responsible for triggering the disease. One placental factor implicated in triggering
preeclampsia is trophoblast debris which may transmit pathogenic signals from the placenta
to endothelial cells. In this study, we investigated whether trophoblast debris from
preeclamptic placentae triggered endothelial cell activation. Methods Trophoblast debris …
mechanisms leading to preeclampsia are unclear, a factor (s) from the placenta is
responsible for triggering the disease. One placental factor implicated in triggering
preeclampsia is trophoblast debris which may transmit pathogenic signals from the placenta
to endothelial cells. In this study, we investigated whether trophoblast debris from
preeclamptic placentae triggered endothelial cell activation. Methods Trophoblast debris …
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