Tumor cell behavior in porous hydrogels: effect of application technique and doxorubicin treatment

MH Zoughaib, DT Luong, ZY Siraeva… - Bulletin of Experimental …, 2019 - Springer
The effect of porosity on diffusion characteristics of scaffolds and invasive capacity of MCF-7
and PC-3 tumor cells was studied for gelatin hydrogels. According to MTS test results, the
efficiency of population of a macroporous cryogel by cells applied by different techniques
increased in the following order: migration from the monolayer< surface adhesion<<
injection. Tumor cells in the cryogel differed by the migration and aggregation activity;
injection route ensured a more uniform and dense population. In the cryogel-based culture …

Tumor Cell Behavior in Porous Hydrogels: Effect of Application Technique and Doxorubicin Treatment

S Kuznetsova, M Zoughaib, T Abdullin, D Luong… - dspace.kpfu.ru
The effect of porosity on diffusion characteristics of scaffolds and invasive capacity of MCF-7
and PC-3 tumor cells was studied for gelatin hydrogels. According to MTS test results, the
efficiency of population of a macroporous cryogel by cells applied by different techniques
increased in the following order: migration from the monolayer<surface adhesion<<injection.
Tumor cells in the cryogel differed by the migration and aggregation activity; injection route
ensured a more uniform and dense population. In the cryogel-based culture, the cytotoxic …
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