… of immune recognition of tumor antigens. To address this gap, we analyzed predicted
neopeptides and immune activity in 6,324 human cancer samples from The Cancer Genome Atlas (…

… were also shown to be present in human cancers (19–21); of … mean DAI, survival, and
measures of immune activity support … and although sufficient to elicit tumor immunity in vivo, it is …

… tumor survival prognosis and immune checkpoint blockade responses. The development of
cancer … underlying neoantigen-induced anti-tumor immune response and by streamlining the …

… the immune system to discriminate tumor neopeptides from … immune functions and induces
the development and survival … samples more systematically, we employed the Tumor Immune …

… of anti-tumor immunity, although many other cell types play facilitating and antagonistic roles
as … nor progression-free survival in virtually every major cancer type tested, while low affinity …

… of PDA to immune checkpoint blockade (ICB) is essentially unique across human cancer
histologies. Classically, PDA exhibits an immunologically “cold” tumor microenvironment (TME) …

… Tumor immunity and survival as a function of alternative neopeptides in human cancer. … of
treatment resistance due to tumor evolution and selective immune pressure. Finally, although …

… Deep tumor regressions achievable in multiple cancers with checkpoint inhibitory … The
extent of intratumoral T cell infiltration positively predicts overall survival across many cancer types…

… with survival after PD-1 checkpoint therapy in patients with non-small cell lung cancer …
antigen.garnish parses input variants to generate all possible neopeptide sequences. After …

… Note the presence of clones recognizing both neopeptides … -existing microbial and anti-tumour
immunity in LTSs. Instead, our … As an alternative hypothesis, fitness in the neoantigen load …