Tumor suppressor Par-4 regulates complement factor C3 and obesity
N Araujo, J Sledziona, SK Noothi, R Burikhanov… - Frontiers in …, 2022 - frontiersin.org
Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in
cancer cells. However, the physiological function of Par-4 remains unknown. Here we show
that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par-4 knockout
(AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow
diet. Par-4-/-and AKO mice exhibit increased absorption and storage of fat in adipocytes.
Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53 …
cancer cells. However, the physiological function of Par-4 remains unknown. Here we show
that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par-4 knockout
(AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow
diet. Par-4-/-and AKO mice exhibit increased absorption and storage of fat in adipocytes.
Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53 …
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