Two new 2, 5-diketopiperazines produced by Streptomyces sp. SC0581
L Yang, A Mahal, Y Liu, H Li, P Wu, J Xue, L Xu… - Phytochemistry …, 2017 - Elsevier
L Yang, A Mahal, Y Liu, H Li, P Wu, J Xue, L Xu, X Wei
Phytochemistry Letters, 2017•ElsevierTwo new diketopiperazines, cyclo (l-Phe-l-NMe-DOPA)(2) and cyclo [l-Phe-l-(NMe-3-(NMe-3-
O-α-l-rhamnopyranosyl)-DOPA](3), along with a known diketopiperazine (1), were isolated
from the cultures of Streptomyces sp. SC0581. Their structures were elucidated by extensive
spectroscopic analysis, single-crystal X-ray crystallographic analysis, and chemical
correlation. Compounds 1− 3 exhibited more potent ABTS radical cation scavenging activity
(IC 50 values: 3.7− 14.6 μM) than l-ascorbic acid (IC 50: 17.7 μM). Compounds 2 and 3 also …
O-α-l-rhamnopyranosyl)-DOPA](3), along with a known diketopiperazine (1), were isolated
from the cultures of Streptomyces sp. SC0581. Their structures were elucidated by extensive
spectroscopic analysis, single-crystal X-ray crystallographic analysis, and chemical
correlation. Compounds 1− 3 exhibited more potent ABTS radical cation scavenging activity
(IC 50 values: 3.7− 14.6 μM) than l-ascorbic acid (IC 50: 17.7 μM). Compounds 2 and 3 also …
Abstract
Two new diketopiperazines, cyclo(l-Phe-l-NMe-DOPA) (2) and cyclo[l-Phe-l-(NMe-3-(NMe-3-O-α-l-rhamnopyranosyl)-DOPA] (3), along with a known diketopiperazine (1), were isolated from the cultures of Streptomyces sp. SC0581. Their structures were elucidated by extensive spectroscopic analysis, single-crystal X-ray crystallographic analysis, and chemical correlation. Compounds 1 − 3 exhibited more potent ABTS radical cation scavenging activity (IC50 values: 3.7 − 14.6 μM) than l-ascorbic acid (IC50: 17.7 μM). Compounds 2 and 3 also showed remarkable DPPH radical scavenging activity.
Elsevier
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