Unravelling spinal circuits of pain and mechanical allodynia
V Gangadharan, R Kuner - Neuron, 2015 - cell.com
Neuron, 2015•cell.com
How do spinal circuits mediating tactile sensation and pain get entangled to evoke
allodynia, ie, pain sensation, in response to a normally innocuous stimulus? Recent
breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons
and their polysynaptic connectivity to calretinin-expressing neurons are now identified as
key determinants of the spinal circuitry underlying mechanical allodynia.
allodynia, ie, pain sensation, in response to a normally innocuous stimulus? Recent
breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons
and their polysynaptic connectivity to calretinin-expressing neurons are now identified as
key determinants of the spinal circuitry underlying mechanical allodynia.
How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underlying mechanical allodynia.
cell.com
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