Unsupervised learning for cell-level visual representation in histopathology images with generative adversarial networks

B Hu, Y Tang, I Eric, C Chang, Y Fan… - IEEE journal of …, 2018 - ieeexplore.ieee.org
B Hu, Y Tang, I Eric, C Chang, Y Fan, M Lai, Y Xu
IEEE journal of biomedical and health informatics, 2018ieeexplore.ieee.org
The visual attributes of cells, such as the nuclear morphology and chromatin openness, are
critical for histopathology image analysis. By learning cell-level visual representation, we
can obtain a rich mix of features that are highly reusable for various tasks, such as celllevel
classification, nuclei segmentation, and cell counting. In this paper, we propose a unified
generative adversarial networks architecture with a new formulation of loss to perform robust
cell-level visual representation learning in an unsupervised setting. Our model is not only …
The visual attributes of cells, such as the nuclear morphology and chromatin openness, are critical for histopathology image analysis. By learning cell-level visual representation, we can obtain a rich mix of features that are highly reusable for various tasks, such as celllevel classification, nuclei segmentation, and cell counting. In this paper, we propose a unified generative adversarial networks architecture with a new formulation of loss to perform robust cell-level visual representation learning in an unsupervised setting. Our model is not only label-free and easily trained but also capable of cell-level unsupervised classification with interpretable visualization, which achieves promising results in the unsupervised classification of bone marrow cellular components. Based on the proposed cell-level visual representation learning, we further develop a pipeline that exploits the varieties of cellular elements to perform histopathology image classification, the advantages of which are demonstrated on bone marrow datasets.
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