Up-regulation of components of the renin-angiotensin system in the bile ductligated rat liver

G Paizis, ME Cooper, JM Schembri, C Tikellis… - Gastroenterology, 2002 - Elsevier
… and kidney, whereas blockade of the renin angiotensin system (RAS) attenuates injury. This
… the liver and examines its regulation in the bile ductligation model of hepatic fibrogenesis. …

… -(1–7), an alternative metabolite of the reninangiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat

JS Lubel, CB Herath, J Tchongue, J Grace, Z Jia… - Clinical …, 2009 - portlandpress.com
… there is up-regulation of both classical and novel components of the RAS [17]. In BDL rats,
serum … on 4 μm sections of paraffin-embedded rat liver tissue-mounted on silane-coated glass …

Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation

SH Afroze, MK Munshi, AK Martínez… - … and Liver …, 2015 - journals.physiology.org
… In this study, we used normal and BDL rats that were treated with control, angiotensin II (…
of RAS components in the bile ducts of BDL rat liver sections compared with normal rat as …

[PDF][PDF] Systemic infusion of angiotensin II exacerbates liver fibrosis in bile ductligated rats

R Bataller, E Gäbele, CJ Parsons, T Morris… - …, 2005 - Wiley Online Library
… increased systemic levels of Ang II in rats undergoing bile duct ligation. Ang II infusion into
Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver. …

The role of renin-angiotensin system modulation on treatment and prevention of liver diseases

SM de Macêdo, TA Guimarães, JD Feltenberger… - Peptides, 2014 - Elsevier
… some RAS components were up-regulated in rat liver fibrosis and … with up-regulation of
ACE2, Mas and hepatic conversion of … Bile duct ligation (BDL) rats showed a significant gradual …

Up-regulation of components of the reninangiotensin system in liver fibrosis in the rat induced by CCL4

W Zhang, JF Miao, PF Li, YX Wang… - Research in veterinary …, 2013 - Elsevier
… Total RNA was extracted from rat liver using TRNZOL reagent according to the manufacturer’s
… Knockout of the ACE2 gene in mice aggravated liver fibrosis following bile duct ligation or …

The role of the reninangiotensin system in liver fibrosis

MK Munshi, MN Uddin… - Experimental biology and …, 2011 - journals.sagepub.com
… RAS components in the liver in different animal models of hepatic … upregulated by bile duct
ligation (BDL) in total liver and were … The reninangiotensin system in a rat model of hepatic

The reninangiotensin system in a rat model of hepatic fibrosis: Evidence for a protective role of Angiotensin-(1–7)

RM Pereira, RAS Dos Santos, MM Teixeira… - Journal of …, 2007 - Elsevier
… the plasma levels of components of the RAS in a rat model of bile duct ligation (BDL) and …
components in the livers of BDL rats. More recently, the same group observed an up-regulation

Liver fibrogenesis: a new role for the reninangiotensin system

R Bataller, P Sancho-Bru, P Ginês… - Antioxidants & redox …, 2005 - liebertpub.com
… Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. … Up-regulation
of components of the reninangiotensin system in the bile duct-ligated rat liver. …

Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1–7) levels in experimental biliary fibrosis

CB Herath, FJ Warner, JS Lubel, RG Dean, Z Jia… - Journal of …, 2007 - Elsevier
… II in liver disease. We examined the expression of these novel components of the renin
angiotensin system (… and vasoactive effects of angiotensin-(1–7) in the bile duct ligated (BDL) rat. …