Epidemiologic evidence supported an inverse association between HDL (high-density
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease
(ASCVD), identifying HDL-C as a major cardiovascular risk factor and postulating diverse
HDL vascular-and cardioprotective functions beyond their ability to drive reverse cholesterol
transport. However, the failure of several clinical trials aimed at increasing HDL-C in patients
with overt cardiovascular disease brought into question whether increasing the cholesterol …