Many common cancers have a propensity to metastasize to bone. Although malignancies
often go undetected in their native tissues, bone metastases produce excruciating pain that
severely compromises patient quality of life. Cancer-induced bone pain (CIBP) is poorly
managed with existing medications, and its multifaceted etiology remains to be fully
elucidated. Novel analgesic targets arise as more is learned about this complex and distinct
pain state. Over the past two decades, multiple animal models have been developed to …