Using acute optic neuritis trials to assess neuroprotective and remyelinating therapies in multiple sclerosis

M Andorra, S Alba-Arbalat, A Camos-Carreras… - JAMA …, 2020 - jamanetwork.com
Importance Neuroprotective and remyelinating therapies are required for multiple sclerosis
(MS), and acute optic neuritis (AON) is a potential condition to evaluate such treatments.
Objective To comprehensively assess key biological and methodological aspects of AON
trials for testing neuroprotection and remyelination in MS. Design, Setting, and Participants
The AON-VisualPath prospective cohort study was conducted from February 2011 to
November 2018 at the Hospital Clinic of University of Barcelona, Barcelona, Spain …
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