Uterine leiomyomas, current concepts: pathogenesis, impact on reproductive health, and medical, procedural, and surgical management

MG Munro - Obstetrics and Gynecology Clinics, 2011 - obgyn.theclinics.com
Uterine leiomyomas are extremely common neoplasms that by the age of 50 are found in the
uterus of almost 70% of white women and more than 80% of women of African ancestry. 1
Growth of leiomyomas is largely dependent on female gonadal steroids, especially
estrogens and progesterone, and following menopause they spontaneously regress. The
majority of women who harbor leiomyomas do not experience symptoms such as infertility or
abnormal uterine bleeding (AUB), leading to the conclusion that the vast majority of …
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