Uveal melanoma: laboratory advances and new frontiers in patient care
… Herein, we review the latest advancements in the molecular understanding, diagnosis,
prognostication, and treatment of UM. … Positron Emission Tomography scan
demonstrating uveal melanoma metastasis to the liver and pelvic bone. … In a Phase 1/2
study of 84 patients with metastatic melanoma (61 cutaneous, 19 uveal, and 4 other) treated
with tebentafusp, the 1-year survival rate in the overall cohort was 65%, and overall
response rate in patients with UM was 16% [64▪▪] . Of note, this investigation included only …
prognostication, and treatment of UM. … Positron Emission Tomography scan
demonstrating uveal melanoma metastasis to the liver and pelvic bone. … In a Phase 1/2
study of 84 patients with metastatic melanoma (61 cutaneous, 19 uveal, and 4 other) treated
with tebentafusp, the 1-year survival rate in the overall cohort was 65%, and overall
response rate in patients with UM was 16% [64▪▪] . Of note, this investigation included only …
Summary
Improved understanding of UM molecular pathogenesis and clinical trials of targeted therapy for prevention and treatment of metastatic disease may improve patient survival for this challenging disease.
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