VEGFR2 and hepatocellular carcinoma inhibitory activities of trisubstituted triazole derivatives
The vascular endothelial growth factor receptor 2 (VEGFR2) is considered as a significant
target for inhibition in the discovery of novel molecules with anti-proliferative activity. Here,
we report the synthesis of novel derivatives of 1, 2, 4-triazole as potent VEGFR2 inhibitors
with anti-HCC activity. The chemical structures of the target triazole derivatives were assured
through elemental and spectral analysis. The in vitro anti-VEGFR2 activity of the new
compounds was evaluated. Most compounds revealed promising inhibitory activity in …
target for inhibition in the discovery of novel molecules with anti-proliferative activity. Here,
we report the synthesis of novel derivatives of 1, 2, 4-triazole as potent VEGFR2 inhibitors
with anti-HCC activity. The chemical structures of the target triazole derivatives were assured
through elemental and spectral analysis. The in vitro anti-VEGFR2 activity of the new
compounds was evaluated. Most compounds revealed promising inhibitory activity in …
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