Valacyclovir in primary maternal CMV infection for prevention of vertical transmission: A case-series

M De Santis, M Apicella, C De Luca, L D'Oria… - Journal of Clinical …, 2020 - Elsevier
Background No treatment is currently approved for cytomegalovirus infection in pregnancy.
Valacyclovir has been studied in symptomatic cytomegalovirus infected fetuses and seems
to reduce the risk of serious sequelae. Objectives We used off-label valacyclovir on pregnant
women with primary cytomegalovirus infection to reduce the risk of fetal infection. Study
design We treated 12 pregnant women with 8 g/day valacyclovir after diagnosis of
cytomegalovirus infection until amniocentesis. We continued treatment until delivery in case …
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