Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial
FJK O'Callaghan, SW Edwards, FD Alber… - The Lancet Child & …, 2018 - thelancet.com
Background Infantile spasms constitute a severe form of epileptic encephalopathy. In the
International Collaborative Infantile Spasms Study (ICISS), we showed that combining
vigabatrin with hormonal therapy was more effective than hormonal therapy alone at
stopping spasms between days 14 and 42 of treatment. In this planned follow-up, we aimed
to assess whether combination therapy was associated with improved developmental and
epilepsy outcomes at 18 months of age. Methods In ICISS, a multicentre, open-label …
International Collaborative Infantile Spasms Study (ICISS), we showed that combining
vigabatrin with hormonal therapy was more effective than hormonal therapy alone at
stopping spasms between days 14 and 42 of treatment. In this planned follow-up, we aimed
to assess whether combination therapy was associated with improved developmental and
epilepsy outcomes at 18 months of age. Methods In ICISS, a multicentre, open-label …
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