Although, vitamin K 2 displays vasoprotective effects, it is still not known whether K 2
treatment improves endothelial function. In ApoE/LDLR−/− mice at the stage prior to
atherosclerosis development, four-week treatment with K 2-MK-7, given at a low dose (0.05
mg/kg), improved acetylcholine-and flow-induced, endothelium-dependent vasodilation in
aorta or in femoral artery, as assessed by MRI in vivo. This effect was associated with an
increased NO production, as evidenced by EPR measurements in ex vivo aorta. Treatment …