Whole animal experiments should be more like human randomized controlled trials
BS Muhlhausler, FH Bloomfield, MW Gillman - PLoS Biology, 2013 - journals.plos.org
BS Muhlhausler, FH Bloomfield, MW Gillman
PLoS Biology, 2013•journals.plos.org… Here, we argue that whilst the ARRIVE guidelines are a major step forward, the
standards of reporting animal experiments still lag behind those of RCTs. As a result, the
validity of results from animal studies and their interpretation are frequently in question. We
put forward a series of suggestions for modifying the ARRIVE guidelines to ensure that …
Specifically, we argue that there is a need for more explicit instructions, particularly in
relation to reporting of randomization, blinding, and sample size justification, to ensure that …
standards of reporting animal experiments still lag behind those of RCTs. As a result, the
validity of results from animal studies and their interpretation are frequently in question. We
put forward a series of suggestions for modifying the ARRIVE guidelines to ensure that …
Specifically, we argue that there is a need for more explicit instructions, particularly in
relation to reporting of randomization, blinding, and sample size justification, to ensure that …
The quality of reporting of animal studies lags behind that of human randomized controlled trials but a series of additions to the ARRIVE guidelines will help ensure that the standards are comparable.
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