Whole genome analysis of the action of interferon-β
MA Kauffman, P Yankilevich, PR Barrero, R Bello… - 2009 - ri.conicet.gov.ar
MA Kauffman, P Yankilevich, PR Barrero, R Bello, L Marangunich, A Vidal, M Criscuolo…
2009•ri.conicet.gov.arObjectives: To characterize the IFN1a-regulated gene expression on leukocytes of Multiple
Sclerosis (MS) patients using microarrays with whole human genome representation.
Methods: Genes differentially expressed by interferon-were identified by a microarray in vitro
study performed in leukocytes obtained from 5MS relapsing-remitting patients. Results:
Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting
patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased …
Sclerosis (MS) patients using microarrays with whole human genome representation.
Methods: Genes differentially expressed by interferon-were identified by a microarray in vitro
study performed in leukocytes obtained from 5MS relapsing-remitting patients. Results:
Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting
patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased …
Objectives
To characterize the IFN1a-regulated gene expression on leukocytes of Multiple Sclerosis (MS) patients using microarrays with whole human genome representation.
Methods
Genes differentially expressed by interferon- were identified by a microarray in vitro study performed in leukocytes obtained from 5MS relapsing-remitting patients.
Results
Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased (including CXCL11, CCL8, INDO, IFI27, CFB, CXCL10 and IFIT1) and 323 diminished (including RBP7, SEPT5, RNF8, ADORA2B and FOS).
Conclusions
Since many of them were previously recognized as involved in MS pathogenesis, the IFNb1a mechanism of action could imply a compensatory regulation of systems deregulated in MS.
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