[HTML][HTML] Whole-genome sequencing reveals mutational signatures related to radiation-induced sarcomas and DNA-damage-repair pathways
E Kim, DJ Han, BH Kim, J Yoo, HJ Kim, HG Wu… - Modern Pathology, 2023 - Elsevier
Radiation-induced sarcoma (RIS) is a rare but serious late complication arising from
radiotherapy. Despite unfavorable clinical outcomes, the genomic footprints of ionizing
radiation in RIS development remain largely unknown. Hence, this study aimed to
characterize RIS genomes and the genomic alterations in them. We analyzed whole-
genome sequencing in 11 RIS genomes matched with normal genomes to identify somatic
alterations potentially associated with RIS development. Furthermore, the abundance of …
radiotherapy. Despite unfavorable clinical outcomes, the genomic footprints of ionizing
radiation in RIS development remain largely unknown. Hence, this study aimed to
characterize RIS genomes and the genomic alterations in them. We analyzed whole-
genome sequencing in 11 RIS genomes matched with normal genomes to identify somatic
alterations potentially associated with RIS development. Furthermore, the abundance of …
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