Using family resilience and ecological theories, we examine the relationship between partner work‐required travel separations and spouse psychological well‐being. The study examines the role of work‐organization‐provided supports for families and of informal support networks, including marital satisfaction, as factors that can reduce the risks for indicators of poor well‐being. The data come from a probability sample survey of 8,056 female spouses of U.S. Army personnel, with considerable variation in the amount of travel‐related separations. Findings indicate risks for poor psychological well‐being are greater for spouses who experience more frequent work‐related separations. Findings also indicate that both work organization support and informal support network connections are significant protective factors for spouses experiencing these separations.