This study focuses on perceived discrimination experienced by transgender employees and examines the relative importance of both external (organizational policies and supportive coworkers) and internal (transgender employees’ openness) factors that influence this perceived discrimination. Data from 118 transgender employees revealed that external supports via organizational policies and coworker reactions were significantly related to lower perceptions of discrimination; however, internal support via openness about one’s transgender identity was not related to lower perceptions of discrimination. Importantly, this study also examined the relative importance of these predictors of discrimination and found that the reaction of coworkers was the most salient factor. Such results provide insight on a group of employees that has received relatively little attention in the academic literature and highlight successful efforts—particularly those of supportive coworkers—that can be made to reduce the perceived discrimination that transgender employees may experience.(PsycINFO Database Record (c) 2016 APA, all rights reserved)