Zinc sensing and regulation in yeast model systems
The Zap1 transcription factor of Saccharomyces cerevisiae and the Loz1 transcription factor
of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling
the expression of genes necessary for zinc metabolism. Zap1 activates gene expression
when cells are limited for zinc, while Loz1 is required for gene repression when zinc is in
excess. In this review we highlight what is known about the underlying mechanisms by
which these factors are regulated by zinc, and how transcriptional activation and repression …
of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling
the expression of genes necessary for zinc metabolism. Zap1 activates gene expression
when cells are limited for zinc, while Loz1 is required for gene repression when zinc is in
excess. In this review we highlight what is known about the underlying mechanisms by
which these factors are regulated by zinc, and how transcriptional activation and repression …
Abstract
The Zap1 transcription factor of Saccharomyces cerevisiae and the Loz1 transcription factor of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling the expression of genes necessary for zinc metabolism. Zap1 activates gene expression when cells are limited for zinc, while Loz1 is required for gene repression when zinc is in excess. In this review we highlight what is known about the underlying mechanisms by which these factors are regulated by zinc, and how transcriptional activation and repression in eukaryotic cells can be finely tuned according to intracellular zinc availability.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果