… in the pathophysiology of lung cancer. The primary objective of this review article is to discuss
the function of the acetylcholine-signaling proteins in the progression of lung cancer. The …

Nicotinic acetylcholine receptors (nAChR) are expressed on non-neuronal cell types, including
normal bronchial epithelial cells, and nicotine has been reported to cause Akt activation …

… cholinergic signaling. Thus a first step in analyzing the potential to target non-neuronal …
signaling in lung cancer is to compare cholinergic signaling in lung to cholinergic signaling …

… signaling pathways in intestines and gastric cancer (31), we hypothesized that ACh signaling
may regulate the emergence of drug tolerance, potentially by activating WNT signaling. …

… That multiple stimuli can activate numerous lung cancer signaling pathways may
underlie the resistance of this disease to currently available therapies. It may also provide a …

… cancers, including lung cancer. Hypoxia-inducible factor-1α (HIF-1α) is overexpressed in
human lung cancers, particularly in non–small cell lung cancers (… ), in human lung cancer cells. …

… lung cancer in the nAChR gene cluster, the roles of nicotine receptors, and the molecular
mechanisms of acetylcholine … nAChR signaling pathway has considerable implications for lung …

… signaling pathway are altered in human lung cancer. We show that levels three
acetylcholine-signaling proteins namely ChAT, VAChT and AChE are significantly altered in lung …

… of cancer-related death worldwide [1]. Lung cancer can be divided into small cell lung cancer
(… The EGFR/PI3K/AKT is an important signaling pathway in regulating proliferation and …

… The 15q24-25 region encompasses the nicotinic acetylcholine receptor subunit genes (…
acetylcholine receptor and lung cancer. In patients diagnosed with smoking-related lung cancer …