… mechanism of AP-1 and transformation inhibition in this cell culture model may involve the
elevation of H + concentration. The inhibition effects on the activation … mechanism of action of …

… mediated by the nuclear factor-κB and the activator protein-1, which can both be modulated
… the late 1940s, the molecular mechanisms responsible for their antiinflammatory activity are …

… time course of activated protein C inhibition by PCI at various concentrations in the absence
(A) and presence (B) of 5 units/ml of heparin. Inhibition velocity of activated protein C by PCI …

… Thus, the direct inhibition of the catalyst by beta … likely mechanism involved in receptor-mediated
inhibition of adenylate cyclase, in addition to the previously proposed indirect inhibition …

… We further show that PAI-1 inhibition of the Glu 192 → Gln mutant of APC is enhanced ∼40-…
the inhibitory interaction of PAI-1 with Glu 192 . Additionally, we show that PAI-1 inhibition of …

… activation mechanism. Structural elucidations over the last few years of caspases, caspase
inhibitors and caspase–inhibitor … many of the ideas of caspase activation and regulation. This …

… This entirely distinct mechanism for PKCδ regulation by translocation inhibitor or activator …
The chimaerins (a family of Rac GTPase-activating proteins), RasGRPs (Ras/Rap1 exchange …

… mechanism by which U0126 and PD 184352 exert their effects in io is therefore similar to
that of PD 98059. U0126 inhibited a few other protein … to suppress the activation of MKK1 and …

… strong activity as an inhibitor and the … mechanism for the inhibition of AP-1 activity and cell
growth. The well established ras signal transduction pathway involves the activation of protein …

… tissue or urokinase type plasminogen activator (tPA or uPA), … into the β sheet A of the inhibitor
in a manner that exposes the … A and that this process is central to the inhibition mechanism. …