Early alphafetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma

YY Shao, ZZ Lin, C Hsu, YC Shen, CH Hsu… - Cancer, 2010 - Wiley Online Library
… Antiangiogenic therapy has become the most important treatment modality for patients with
advanced … levels of alpha-fetoprotein (AFP) as a potential biomarker for treatment efficacy of …

Role of α-fetoprotein in hepatocellular carcinoma: prognostication, treatment monitoring or both?

SL Chan, ATC Chan, W Yeo - Future oncology, 2009 - Taylor & Francis
… of treatment response. In this review, the evidence regarding the prognostic value of serum
α-fetoprotein and the value of serial α-fetoprotein in the monitoring of treatment efficacy will …

Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma

N Personeni, S Bozzarelli, T Pressiani, L Rimassa… - Journal of …, 2012 - Elsevier
… surrogate efficacy measure for new cancer treatments. However, in patients treated with …
We investigated the prognostic usefulness of a decrease in serum alpha-fetoprotein (AFP) …

[HTML][HTML] Serum alpha-fetoprotein and clinical outcomes in patients with advanced hepatocellular carcinoma treated with ramucirumab

AX Zhu, RS Finn, YK Kang, CJ Yen, PR Galle… - British journal of …, 2021 - nature.com
… between changes in AFP during treatment and outcomes of efficacy measures in the pooled
population of patients with AFP ≥ 400 ng/ml, in both the REACH-2 and REACH studies. …

Early changes in alpha-fetoprotein are a useful predictor of efficacy of atezolizumab plus bevacizumab treatment in patients with advanced hepatocellular carcinoma

T Kuzuya, N Kawabe, S Hashimoto, R Miyahara… - Oncology, 2022 - karger.com
alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) levels in patients with advanced
hepatocellular carcinoma (HCC) treated … tumor markers and treatment efficacy. Methods: …

[HTML][HTML] Alpha-fetoprotein predicts the treatment efficacy of immune checkpoint inhibitors for gastric cancer patients

J Zhang, L Wang, S Zhang, R Cao, Y Zhao, Y Zhao… - BMC cancer, 2024 - Springer
… patients who underwent ICI treatment. The patients were divided into high and low groups
based on the AFP threshold of 20 ng/ml. The efficacy of ICI treatment was assessed using …

[HTML][HTML] Association between early response of alpha-fetoprotein and treatment efficacy of systemic therapy for advanced hepatocellular carcinoma: A multicenter …

G Hou, B Liu, ZQ Fan, C Li, JP Zhang, YH Guo… - Frontiers in …, 2023 - frontiersin.org
… as an effective tool to assess treatment efficacy and predict tumor … with data on treatment
efficacy monitoring and planning for … As shown in Table 2, we assessed the treatment efficacy in …

The use of alpha-fetoprotein for the treatment of autoimmune diseases and cancer

VN Pak - Therapeutic delivery, 2018 - Taylor & Francis
… On the other hand, hAFP plus methotrexate can be used for treatment of cancer, where … of
efficacy in reducing clinical score of disease activity and increasing muscle strength in treated

[PDF][PDF] Alpha-fetoprotein as a potential surrogate biomarker for atezolizumab+ bevacizumab treatment of hepatocellular carcinoma

AX Zhu, F Dayyani, CJ Yen, Z Ren, Y Bai, Z Meng… - Clinical Cancer …, 2022 - AACR
… Clinicians face difficulty in predicting the efficacy of hepatocellular carcinoma (HCC) 77
treatments as there is no optimal surrogate endpoint for overall survival. Further, 78 …

[HTML][HTML] Post-treatment alpha-fetoprotein response predicts prognosis of patients with hepatocellular carcinoma: A meta-analysis

C He, W Peng, X Liu, C Li, X Li, TF Wen - Medicine, 2019 - journals.lww.com
Background: Post-treatment alpha-fetoprotein (AFP) response has been reported to be
associated with prognosis of hepatocellular carcinoma (HCC) patients, but the results were not …