… (28) The presence within this series of compounds of an α-iminophosphonate unit, also …
our research with this family of bicyclic α-iminophosphonates with the twofold aim of further …

… a new family of bicyclic α-iminophosphonates endowed with relevant … Additionally, in vivo
studies in the familial Alzheimer’s disease … decline and Alzheimer’s disease. Therefore bicyclic …

… I 2 -IR ligands in a transgenic Alzheimer’s disease Caenorhabditis elegans strain are … in
this in vivo model after treatment with the new bicyclic α-phosphoprolines. Therefore, our results …

… Other biologically significant α-substituted phosphonates and phosphonic acids are also
readily … One of the causes of Alzheimer’s disease is a lack of acetylcholine in the brain, so …

… , a family of bicyclic α-iminophosphonates, endowed with high … decline and the other for
Alzheimer’s disease (AD), with … a family of bicyclic α-iminophosphonates synthetised by a [3+2]…

… Cluster 1 represents compounds synthesized in this manuscript, while cluster 2 contains
bicyclic α-iminophosphonate I 2 -IR ligands previously described by our group (Fig. S1) [23]. To …

… disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease,
… I2-IR ligands, with its bicyclic αiminophosphonate structure being the first described non-…

… The α-amino phosphorus compounds, including α-amino phosphonic acids and phosphines,
have … Chapter 1 of this thesis is a general introduction to the synthetic chemistry related to α-…

… previously described by our group (10 bicyclic α-iminophosphonates and 9 benzofuranyl-2-imidazole …
derivatives and the other consisting of bicyclic α-iminophosphonates (Figure S1). …

… bicyclic α-iminophosphonates, none of the compounds exerted any cytotoxicity (Abás …
In the present study, only β-iminophosphonate 4e revealed significant antiproliferative and …