Expression and degradation of androgen receptor: mechanism and clinical implication
DK Lee, C Chang - The Journal of Clinical Endocrinology & …, 2003 - academic.oup.com
… androgens is mediated by androgen receptor (AR), a member of the steroid hormone receptor
… AR to interact with androgen response elements (ARE) in various androgen target genes (…
… AR to interact with androgen response elements (ARE) in various androgen target genes (…
Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting
ES Antonarakis, AJ Armstrong, SM Dehm… - Prostate cancer and …, 2016 - nature.com
… androgen receptor and androgen receptor splice variants. Full-length androgen receptor
and androgen receptor … Androgen receptor splice variants (AR-Vs) lack the AR ligand-binding …
and androgen receptor … Androgen receptor splice variants (AR-Vs) lack the AR ligand-binding …
Androgen receptor coregulators in prostate cancer: mechanisms and clinical implications
M Rahman, H Miyamoto, C Chang - Clinical cancer research, 2004 - AACR
The transcriptional activity of androgen receptor (AR) is modulated by coregulators that
have a significant influence on a number of functional properties of AR, including the ligand …
have a significant influence on a number of functional properties of AR, including the ligand …
Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications
C Pisano, M Tucci, RF Di Stefano, F Turco… - Critical reviews in …, 2021 - Elsevier
… Androgen receptor (AR) is considered the main driver in PCa … androgen receptor and other
molecular pahtways in prostate cancer. TKR: tyrosine kinase receptor; AR: androgen receptor…
molecular pahtways in prostate cancer. TKR: tyrosine kinase receptor; AR: androgen receptor…
Selective androgen receptor modulators: current knowledge and clinical applications
ZJ Solomon, JR Mirabal, DJ Mazur… - Sexual medicine …, 2019 - academic.oup.com
… Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors
depending on each SARM’s chemical structure. As a result, SARMs result in anabolic cellular …
depending on each SARM’s chemical structure. As a result, SARMs result in anabolic cellular …
[HTML][HTML] Androgen receptor and prostate cancer stem cells: biological mechanisms and clinical implications
Prostate cancer (PCa) contains phenotypically and functionally distinct cells, and this cellular
heterogeneity poses clinical challenges as the distinct cell types likely respond differently …
heterogeneity poses clinical challenges as the distinct cell types likely respond differently …
Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure
S Kimura, T Matsumoto, R Matsuyama, H Shiina… - Trends in Endocrinology …, 2007 - cell.com
… An initial step to answering this question is to understand the function of androgen receptors
… of androgens is exerted through transcriptional regulation by the nuclear androgen receptor …
… of androgens is exerted through transcriptional regulation by the nuclear androgen receptor …
[HTML][HTML] The role of the androgen receptor in ovarian cancer carcinogenesis and its clinical implications
H Zhu, X Zhu, L Zheng, X Hu, LZ Sun, X Zhu - Oncotarget, 2017 - ncbi.nlm.nih.gov
… We also summarize and discuss key data describing clinical implications in ovarian cancer.
A better understanding on the activity and clinical relevance of the steroid hormone receptor …
A better understanding on the activity and clinical relevance of the steroid hormone receptor …
[HTML][HTML] Androgen receptor in breast cancer—clinical and preclinical research insights
… , clinical studies, and clinical trials, we summarize the biology of AR, its prognostic and
predictive value, as well as its therapeutic implications by breast cancer molecular subtype. …
predictive value, as well as its therapeutic implications by breast cancer molecular subtype. …
[HTML][HTML] Androgen receptor in breast cancer and its clinical implication
H Hackbart, X Cui, JS Lee - Translational Breast Cancer Research, 2023 - ncbi.nlm.nih.gov
… (PR), and human epidermal growth factor receptor-2 (HER2). In addition to these receptors,
the presence of the androgen receptor (AR) in breast cancer cells adds a layer of complexity …
the presence of the androgen receptor (AR) in breast cancer cells adds a layer of complexity …
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