Alkaloids: a source of anticancer agents from nature

AP Gupta, P Pandotra, M Kushwaha, S Khan… - Studies in natural …, 2015 - Elsevier
Indole alkaloids show different type of biological activities such as cytotoxic, antitumor,
antiviral, antimicrobial, antiparasitics, antiserotonin, and anti-inflammatory [105]. Due to the …

Recent progress in biological activities of indole and indole alkaloids

TP Singh, OM Singh - Mini reviews in medicinal chemistry, 2018 - ingentaconnect.com
Indole alkaloids such as tryptophan 2 are well known for their … are well established and
further Indole3-acetic acid 6 as … -indole was examined for in vitro antitumor activity against …

Natural indole‐containing alkaloids and their antibacterial activities

Y Liu, Y Cui, L Lu, Y Gong, W Han… - Archiv der …, 2020 - Wiley Online Library
… that it could serve as a lead hit for the development of antibacterial and anticancer agents. …
Bisindole alkaloids, consisting of two monomeric indole alkaloid units, usually showed a …

Bis-indole alkaloid caulerpin from a new source Sargassum platycarpum: isolation, characterization, in vitro anticancer activity, binding with nucleobases by DFT …

DA Abdelrheem, HR Abd El-Mageed… - Journal of …, 2021 - Taylor & Francis
… Caulerpin, a bis-indole alkaloid is isolated from a new source … In vitro anticancer activity of
caulerpin has been explored by … encourage for future in vivo anticancer study. The binding of …

Molecular targets and anticancer potential of indole-3-carbinol and its derivatives

BB Aggarwal, H Ichikawa - Cell cycle, 2005 - Taylor & Francis
… The types of vegetables and fruits, that most often appear to be protective against cancer are
… fruit that may help protect against cancer include dithiolthiones, isothiocyanates, indole-3-…

Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line

F Tabassum, CM Hasan, MM Masud, S Jamshidi… - Phytochemistry, 2021 - Elsevier
… undescribed indole alkaloids, 3-prenyl-5(3-keto-but-1-enyl) indole and 3-prenyl-indole-5-carbaldehyde,
the structurally-related 3,5-diprenyl indole and four known alkaloids were …

Alkaloids as potential anticancer agent

MA Patil, AP Sarkate, NP Nirmal, BK Sakhale - Recent Frontiers of …, 2023 - Elsevier
… A dimeric indole alkaloid, namely, montamine, was screened and quantified from the seeds
(… , a dimeric indole alkaloid with an IC50 of 43.9 µm, showed substantial anticancer activity in …

Anticancer effects of brominated indole alkaloid Eudistomin H from marine ascidian Eudistoma viride against cervical cancer cells (HeLa)

RP Rajesh, M Annappan - Anticancer Research, 2015 - ar.iiarjournals.org
… The active EHF-21 fraction, a brominated indole alkaloid Eudistomin H, led to apoptotic …
With this in mind, we investigated the cytotoxic potential of compounds from the ascidian …

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)

P Dey, A Kundu, A Kumar, M Gupta, BM Lee… - Recent advances in …, 2020 - Elsevier
… Eudistomin K (isolated from Caribbean ascidian Eudistoma olivaceum) is an indole alkaloid,
which contains a novel oxathiazepine ring, and is found to be an antitumor lead against L-…

Indole-fused azepines and analogues as anticancer lead molecules: privileged findings and future directions

AK Singh, V Raj, S Saha - European journal of medicinal chemistry, 2017 - Elsevier
indole alkaloids along with meridianins (1C) and their synthetic analogs (indolylpyrimidines)
also exhibit potent anticancer … Among them, antimitotic agent colchicine (1D) has potential