… Memory CD4 T cell responses are functionally and phenotypically … T cell responses were
analyzed in different models of Ag-specific immune responses differing on Ag exposure and/or …

… central memory T cells (6–9). We focused on responses to two secreted antigens encoded by
the … of effector T-cell responses in recently exposed contacts; second, to compare effector T-…

… understanding of how B cell responses are initiated; the … -lived plasma cells, germinal center
cells, and memory cells; and … how B cells travel throughout the body surveying for antigen, …

… -specific T-cell responses are shown on the left side of the figure (shaded in blue) whereas
those impacting on T-cell dysfunction or deletion of virus-specific T-cell responses are shown …

… Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

… To study the influence of antigen dose and persistence on CD4 + T cell responses in vivo,
we generated double transgenic mice expressing an antigenic peptide from moth cytochrome …

… T cells during both primary and secondary immune responses. Our results show that with
repeated or prolonged exposure to antigen, limiting doses of antigen select for T cells with …

… cell response by targeting the antigen to a draining lymph node. And finally, we tested the
effect of IS on this antigen specific T cell response. … -specific T cells, resulting in less T cell help …

… Our results also suggest that time-controlled antigen exposure may be a means for vaccine
optimization and therapeutic tolerance induction. In that sense the present results hark back …

… + T cell response following primary or repeated viral infection. Maturation of B cell responses
to antigen … antigen-driven selection for cells expressing receptors with the highest affinity for …