An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi… - Biochemical and …, 1997 - Elsevier
… ment] type-Maf recognition element (T-MARE; 12). This resemblance provided our initial
insight into the and Nrf2-small Maf heterodimers. role that the small Maf proteins may be an …

Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes

F Katsuoka, H Motohashi, T Ishii… - … and cellular biology, 2005 - Am Soc Microbiol
Maf proteins form homodimers, various combinations of small Maf heterodimers, heterodimers
… and p45 NF-E2), and heterodimers with the transcriptional repressor Bach proteins Bach1 …

Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD (P) H: Quinone …

S Dhakshinamoorthy, AK Jaiswal - Journal of Biological Chemistry, 2000 - ASBMB
Maf-Maf homodimers and Maf-Nrf2 heterodimers. Therefore, Maf-Maf homodimers and
possibly Maf-Nrf2 heterodimers … -mediated transcription and antioxidant induction of NQO1 and …

Transcriptional regulation of the antioxidant response element: activation by Nrf2 and repression by MafK

T Nguyen, HC Huang, CB Pickett - Journal of Biological Chemistry, 2000 - ASBMB
… specificities of Nrf2/MafK heterodimers to the ARE derived from … We found that Nrf2/small
Maf heterodimers bind with high … genes; however, small Maf acts as a transcriptional repressor …

[HTML][HTML] Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif

W Li, S Yu, T Liu, JH Kim, V Blank, H Li… - Biochimica et Biophysica …, 2008 - Elsevier
… Nrf2/sMaf heterodimer binds specifically to a cis-acting enhancer called antioxidant response
element and initiates transcription of a battery of antioxidant and detoxification genes. Nrf2 …

[HTML][HTML] Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases

A Otsuki, M Yamamoto - Archives of pharmacal research, 2020 - Springer
… The CNC family of transcription factors, including NRF2, form heterodimers with small Maf
(… as antioxidant response element, electrophile response element, or NF-E2-binding element. …

Nrf2 transcriptionally activates the mafG gene through an antioxidant response element

F Katsuoka, H Motohashi, JD Engel… - Journal of Biological …, 2005 - ASBMB
… that is regulated by an Nrf2/small Maf heterodimer and suggest the presence of an autoregulatory
… By inducing a battery of antioxidant and xenobiotic metabolizing enzymes, such as …

Regulating resistance: CncC: Maf, antioxidant response elements and the overexpression of detoxification genes in insecticide resistance

CS Wilding - Current opinion in insect science, 2018 - Elsevier
… from Keap1, translocates to the nucleus and forms a heterodimer with Maf-S. The CncC/Maf
heterodimer binds to antioxidant response elements (AREs) upstream of target genes and …

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention

JD Hayes, M McMahon - Cancer letters, 2001 - Elsevier
… the expression of detoxication and antioxidant genes. These … occurs through the antioxidant
responsive element (ARE), a … the ARE as heterodimers with either small Maf proteins, FosB…

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

Y Hirotsu, F Katsuoka, R Funayama… - Nucleic acids …, 2012 - academic.oup.com
… Nrf2 heterodimerizes with small Maf (sMaf) proteins and binds to antioxidant response
heterodimers bind to the antioxidant response element (ARE)/electrophile responsive element