Base editing: precision chemistry on the genome and transcriptome of living cells

HA Rees, DR Liu - Nature reviews genetics, 2018 - nature.com
base editors achieve analogous changes using components that target RNA. Base editors
directly convert one base or base … -dividing cells without generating excess undesired editing

Base editing: advances and therapeutic opportunities

EM Porto, AC Komor, IM Slaymaker… - Nature Reviews Drug …, 2020 - nature.com
… in living cells — is one of the most recent advances in the field of genome … cells process
base editing intermediates may additionally inform new therapeutic strategies using base editors

Base editors: modular tools for the introduction of point mutations in living cells

M Evanoff, AC Komor - Emerging topics in life sciences, 2019 - portlandpress.com
… With dozens of base editors now reported, it is … of base editors, each with its own unique
properties and potential uses. In this perspective, we describe currently available base editors, …

Therapeutic base editing of human hematopoietic stem cells

J Zeng, Y Wu, C Ren, J Bonanno, AH Shen, D Shea… - Nature Medicine, 2020 - nature.com
Live cell images were acquired using a Nikon Eclipse Ti inverted microscope. Image
acquisition was performed at room temperature and air in a 24-well plate. Sickled …

Base editing of organellar DNA with programmable deaminases

JS Kim, J Chen - Nature Reviews Molecular Cell Biology, 2024 - nature.com
… in living cells. Recently, CRISPR-free, protein-only base editors, such as double-stranded
DNA … toxin A-derived cytosine base editors (DdCBEs) and adenine base editors (ABEs), have …

Base editing of haematopoietic stem cells rescues sickle cell disease in mice

GA Newby, JS Yen, KJ Woodard, T Mayuranathan… - Nature, 2021 - nature.com
… Adenine base editors (ABEs) convert targeted A•T base pairs to G•C in living cells without
requiring DSBs or donor DNA templates, and with minimal formation of indels 2 . In SCD, the …

Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells.

HA Rees, DR Liu - Nature Reviews. Genetics, 2018 - europepmc.org
The originally published article contained errors in reference numbering throughout table 1 (DNA
base editors and their approximate editing windows) due to the unintended …

GO: a functional reporter system to identify and enrich base editing activity

A Katti, M Foronda, J Zimmerman, B Diaz… - Nucleic acids …, 2020 - academic.oup.com
… Development of a specific cytosine base editing reporter: Cy GO To detect cytosine BE
events in real time in living cells, we sought to create a reporter that would become activated …

Precision genome editing using cytosine and adenine base editors in mammalian cells

TP Huang, GA Newby, DR Liu - Nature protocols, 2021 - nature.com
editing characteristics. Here, we describe a protocol for using base editing in cultured
mammalian cells… We provide guidelines for choosing target sites, appropriate base editor variants …

Bioorthogonally activatable base editing for on-demand pyroptosis

WSC Ngai, S Yang, X Zeng, Y Liu, F Lin… - Journal of the …, 2022 - ACS Publications
… was triggered through Me 2 Tz addition and the editing efficiency was computed as the C:…
base editing activities of BaseBAC over a 48 h time-course. We observed distinct C-to-T editing