… that IL-3 can protect 32Dp210 Bcr-Abl and Baf3p210 Bcr-Abl cells from apoptosis
induced by these compounds suggests that the IL-3-induced cell survival pathway is Src-independent. …

… BCR-ABL expression is inducible by doxycyclin and by using the drug STI571 to inactivate
BCR-ABL … expression in response to IL-3 and BCR-ABL expression, we studied the effects of …

… -length p210 BCR/ABL cDNA. Following transfection, the cells became completely factor-independent
within 3 weeks. We examined the effects of p210 BCR/ABL and IL-3 on the pattern …

… mice in about 3 weeks. This CML-… of Bcr-Abl/p210 was essential for its leukemogenic
potential in vivo. Interestingly, we found that the leukemic cells expressed excess interleukin-3 (IL-3…

… , such as interleukin (IL)-3, to induce β1 integrin-mediated cell adhesion or by the BCR/ABL
fusion … B210, stimulated with IL-3 or inducibly expressing BCR/ABL. Furthermore, Rap1 …

… )-3 can modulate the outcome of cellular exposure to DNA damage. To determine whether
Bcr-Abl … Mdm2 in the IL-3-dependent pre-B cell line BaF3 and its bcr-abl-transfected derivative …

… Cytokines such as interleukin 3 and granulocyte/macrophage-colony-… Bcr-Abl co-immunoprecipitates
with, and constitutively phosphorylates, the common β c subunit of the interleukin 3 …

… (CML) express aberrant transcripts for interleukin 3 (IL-3) and granulocyte colony-… IL-3 and
anti–IL-3 receptor antibodies. Expression of the product of the Ph chromosome, the BCR/ABL …

… cells display a unique autocrine interleukin 3 (IL-3)/granulocyte–… that BCR-ABL transduction
of primitive Sca-1 + lin − mouse bone marrow (BM) cells causes immediate activation of IL-3, …

… Translocation places the c-abl gene under the transcriptional control of the bcr locus, … by
1 to 3 exons of the bcr gene and by all but the first exon of c-abl. This chimeric bcr-abl protein (…