Benzo (a) pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus

W Dong, L Wang, C Thornton, BE Scheffler, KL Willett - Aquatic Toxicology, 2008 - Elsevier
expression of the P450 enzyme aromatase genes could be a target for reproductive or
developmental dysfunction caused by BaP exposure. Aromatase … are two isoforms of aromatase, a …

Effects of benzo (a) pyrene exposure on killifish (Fundulus heteroclitus) aromatase activities and mRNA

MR Patel, BE Scheffler, L Wang, KL Willett - Aquatic Toxicology, 2006 - Elsevier
mRNA levels, our results showed a seasonal difference in the BaP effects on killifish female
brain aromatase activity. Following the winter BaP exposure female brain aromatase activity …

Altered gene expression: A mechanism for reproductive toxicity in zebrafish exposed to benzo [a] pyrene

JL Hoffmann, JT Oris - Aquatic Toxicology, 2006 - Elsevier
… The objectives of this study were to: (1) determine the effect of exposure to waterborne
benzo[a]pyrene (B[a]P) (0, 1.5 and 3.0μg/L) for 56 days on egg production and OSI in female …

… and PPAR-mediated aromatase downregulation in female Sprague–Dawley rats following combined oral exposure to benzo [a] pyrene and di-(2-ethylhexyl) …

C Xu, JA Chen, Z Qiu, Q Zhao, J Luo, L Yang, H Zeng… - Toxicology letters, 2010 - Elsevier
mRNA levels compared to controls (P < 0.05). Additionally, significant differences of P450Arom
mRNA expression … PPAR-α and PPAR-γ mRNA expression and reached the statistically …

The cigarette smoke constituent benzo [a] pyrene disrupts metabolic enzyme, and apoptosis pathway member gene expression in ovarian follicles

JC Sadeu, WG Foster - Reproductive toxicology, 2013 - Elsevier
… Therefore, the objective of this study was to quantify mRNA expressionmRNA expressions
were lower compared to expression on day 12. While aromatase mRNA expression

Embryonic exposure to benzo (a) pyrene inhibits reproductive capability in adult female zebrafish and correlation with DNA methylation

D Gao, J Lin, K Ou, Y Chen, H Li, Q Dai, Z Yu… - Environmental …, 2018 - Elsevier
… the effects of embryonic short-term exposure to benzo(a)pyrene (BaP), a model … mRNA
levels of follicle-stimulating hormone, luteinizing hormone, ovarian cytochrome P450 aromatase

CYP1C1 Messenger RNA Expression is Inducible by Benzo[a]pyrene in Fundulus heteroclitus Embryos and Adults

L Wang, BE Scheffler, KL Willett - Toxicological sciences, 2006 - academic.oup.com
… CYP1C1 mRNA expression was constitutively higher than CYP1A in brain, spleen, eye,
and gonad, while CYP1A was higher in gastrointestinal tract (GI), heart, gill, and liver. Kidney …

Mechanism of benzo (a) pyrene induction of alpha-human chorionic gonadotropin gene expression in human lung tumor cells.

DT Wong, DK Biswas - The Journal of cell biology, 1985 - rupress.org
… Ectopic hormone and inappropriate gene expression are commonly found to be associated
with neoplastic transformation of cells. BaP and several other members of the PAHs have …

Benzo[a]pyrene Effects on Reproductive Endpoints in Fundulus heteroclitus

F Booc, C Thornton, A Lister, D MacLatchy… - Toxicological …, 2014 - academic.oup.com
aromatase mRNA expression found in both F. heteroclitus larvae and adults (Dong et al.,
2008) and ovarian aromatase … the reduction in aromatase expression would hypothetically lead …

Mechanistic evaluation of benzo [a] pyrene's developmental toxicities mediated by reduced Cyp19a1b activity

KM Alharthy, FF Albaqami, C Thornton… - Toxicological …, 2017 - academic.oup.com
… The focus of this study was on brain aromatase expressed by … ’s ability to disrupt aromatase
gene expression and activity, … no significant effect on cyp19a1b expression in either BaP-…