Benzo[a]pyrene Effects on Reproductive Endpoints in Fundulus heteroclitus

F Booc, C Thornton, A Lister, D MacLatchy… - Toxicological …, 2014 - academic.oup.com
… The aim of this study was to use a fish model, Fundulus heteroclitus, to assess whether BaP
exposure … Steroid concentrations in Fundulus larvae from exposed parents at 1 and 3 weeks …

CYP1C1 Messenger RNA Expression is Inducible by Benzo[a]pyrene in Fundulus heteroclitus Embryos and Adults

L Wang, BE Scheffler, KL Willett - Toxicological sciences, 2006 - academic.oup.com
… Two full-length alleles of Fundulus heteroclitus CYP1C1 complementary DNA were cloned.
… To investigate whether the carcinogen benzo[a]pyrene (BaP) was a CYP1C1 inducer, we …

Benzo (a) pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus

W Dong, L Wang, C Thornton, BE Scheffler, KL Willett - Aquatic Toxicology, 2008 - Elsevier
… The objective of our study was to investigate the potential for benzo(a)pyrene (BaP), a …
CYP19A1 and CYP19A2 mRNA expression in Fundulus heteroclitus. By using in situ hybridization …

Effects of benzo (a) pyrene exposure on killifish (Fundulus heteroclitus) aromatase activities and mRNA

MR Patel, BE Scheffler, L Wang, KL Willett - Aquatic Toxicology, 2006 - Elsevier
… To evaluate the effects of benzo(a)pyrene (BaP), a model carcinogenic PAH and AhR
ligand, on aromatase mRNA expression and enzyme activity, adult Fundulus were exposed to …

Evidence for resistance to benzo [a] pyrene and 3, 4, 3′ 4′-tetrachlorobiphenyl in a chronically polluted Fundulus heteroclitus population

X Arzuaga, A Elskus - Marine environmental research, 2002 - Elsevier
… Resistance to PAHs was examined in a HAH-resistant population of Fundulus heteroclitus
collected from a site contaminated with both compound classes (Newark Bay, NJ). Fish were …

Comparative Chronic Liver Toxicity of Benzo[a]pyrene in Two Populations of the Atlantic Killifish (Fundulus heteroclitus) with Different Exposure Histories

LP Wills, D Jung, K Koehrn, S Zhu… - Environmental …, 2010 - ehp.niehs.nih.gov
… Embryos and larvae of ER killifish (Fundulus heteroclitus) are refractory to the induction
of enzymes regulated by the aryl hydrocarbon receptor including cytochrome P4501A (CYP1A) …

Effects of benzo [a] pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site

D Jung, Y Cho, LB Collins, JA Swenberg, RT Di Giulio - Aquatic toxicology, 2009 - Elsevier
Benzo[a]pyrene (BaP) is a known genotoxicant that affects both mitochondrial and nuclear
DNA (mtDNA, nDNA). Here, we examined mtDNA and nDNA damage in the Atlantic killifish (…

Effect of CYP1A inhibition on the biotransformation of benzo [a] pyrene in two populations of Fundulus heteroclitus with different exposure histories

LP Wills, S Zhu, KL Willett, RT Di Giulio - Aquatic toxicology, 2009 - Elsevier
… Although the sediment is both acutely lethal and teratogenic to a variety of aquatic
organisms, there is a population of Fundulus heteroclitus (killifish) that is thriving at the site. This …

Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides

BW Clark, RT Di Giulio - Ecotoxicology, 2012 - Springer
… The population of Fundulus heteroclitus (the Atlantic killifish or mummichog; hereafter referred
to as killifish) inhabiting the Atlantic Wood Industries Superfund site on the Elizabeth River …

Dietary cadmium and benzo (a) pyrene increased intestinal metallothionein expression in the fish Fundulus heteroclitus

G Roesijadi, S Rezvankhah, A Perez-Matus… - Marine environmental …, 2009 - Elsevier
… Our objective was to determine the effect of dietary exposure to cadmium and co-exposure
to benzo(a)pyrene on metallothionein induction in F. heteroclitus, focusing on expression of …