Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

B Bukowska, K Mokra, J Michałowicz - International journal of molecular …, 2022 - mdpi.com
… B[a]P mainly contributed to cancer development in children in all schools tested. Similarly, the
… morphological and physiological abnormalities in the zebrafish skeleton (head, spine, and …

The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish

SM Billiard, AR Timme-Laragy… - Toxicological …, 2006 - academic.oup.com
… of zebrafish (… of zebrafish AHR2 and CYP1A proteins during development. We observed
that while knock down of AHR2 reduces cardiac toxicity of BNF combined with ANF to zebrafish

Protective effects of genistein and estradiol on PAHs-induced developmental toxicity in zebrafish embryos

X Ren, F Lu, Y Cui, X Wang, C Bai… - Human & …, 2012 - journals.sagepub.com
… In the present study, benzo(a)pyrene (B(a)P) and benzo(k)… and combined developmental
toxicity using zebrafish embryos as … and mortality in developing zebrafish embryos. The toxicity …

Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo [a] pyrene and a complex polycyclic aromatic hydrocarbon …

JB Harris, JH Hartman, AL Luz, JY Wilson, A Dinyari… - Toxicology, 2020 - Elsevier
… to the developmental exposure, we also performed an exposure beginning at the fourth
larval stage (L4) to determine organismal reproductive toxicity, in the absence of developmental

Comparative in vitro metabolism of benzo [a] pyrene by recombinant zebrafish CYP1A and liver microsomes from β-naphthoflavone-treated rainbow trout

CL Miranda, WG Chung, JL Wang-Buhler… - Aquatic Toxicology, 2006 - Elsevier
zebrafish CYP1A converts benzo[a]pyrene to a diol epoxide that binds to DNA. Panel A: HPLC
profile after incubation of calf thymus DNA with zebrafish … 3- 3 H]-benzo[a]pyrene. Note the …

Chronic exposure to environmental concentrations of benzo [a] pyrene causes multifaceted toxic effects of developmental compromise, redox imbalance, and …

R Zeb, X Yin, F Chen, KJ Wang - Aquatic Toxicology, 2024 - Elsevier
… Our study addresses these gaps by evaluating developmental abnormalities, growth disruptions,
… This comprehensive approach provides valuable insights into the early developmental

Benzo (a) pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus

W Dong, L Wang, C Thornton, BE Scheffler, KL Willett - Aquatic Toxicology, 2008 - Elsevier
… study was to investigate the potential for benzo(a)pyrene (BaP), a … effects of exposure at
different developmental stages, we aimed … When protogynic fish like zebrafish were exposed to …

Generation and application of a novel transgenic zebrafish line Tg (cyp1a: mCherry) as an in vivo assay to sensitively monitor PAHs and TCDD in the environment

SL Xie, M Junaid, WP Bian, JJ Luo, JH Syed… - Journal of hazardous …, 2018 - Elsevier
… In this study, an in vivo approach was developed and applied to detect the contamination
level of the PAHs and TCDD in the environment. Our purpose was to create a stable, sensitive, …

Effect of Benzo (a) pyrene on the craniofacial development of zebrafish

B O'Connor - 2015 - dc.uwm.edu
… is to develop exposure windows to identify the developmental process benzo(a)pyrene is
disrupting. … deformities in zebrafish associated with exposure to benzo(a)pyrene resulting in a …

Reproductive and Multigenerational Effects of Dietary Benzo [A] Pyrene Exposure in Zebrafish

M White - 2014 - egrove.olemiss.edu
… Dietary benzo(a)pyrene intake during pregnancy and birth weight: Associations … Benzo[a]pyrene
decreases global and gene specific DNA methylation during zebrafish development. …