… A methodology using biosensor technology for combined kinetic and thermodynamic analysis
of biomolecular interactions is described. Rate and affinity constants are determined with …

… modulators of protein–protein interactions are essential to the … crystal (PC) biosensors and
other emerging technologies can … or enhance protein–protein interactions (167 references). …

… Both of the currently available commercial optical biosensor instruments (the IAsys used
in this study and the BIAcore manufactured by Pharmacia) use a similar surface coating. This …

… from the weak affinity of carbohydrate–protein interactions, the lack of versatile … technology.
In this review, we focus on discussing the characteristics of carbohydrate–protein interactions …

… , simple partition equilibrium experiments and biosensor technology has created a situation
… relatively weak interactions (binding constants less that 103 M À1) to tight interactions with …

… As modulators of protein—protein interactions are valuable as medicinal agents and … to
adapt PC biosensor technology to the detection of protein—protein interactions. As diagrammed …

… a thermody- namic approach to the characterization of protein internamic characterization
of the interaction. actions by biosensor technology is certainly a retreat The present study has …

… in live cells with streamlined co-expression of biosensors in a miniaturized format. We …
interactions, suggesting new mechanisms for regulation of Hippo signaling. Our BRET n biosensor …

Reversible protein phosphorylation of serine, threonine, and tyrosine residues by protein
kinases and phosphatases is important for the regulation of cellular signal transduction and …

… or any potential drug therapy targeting protein interactions must be effective at the cellular
… cellular protein−protein interaction assays, the present study describes a novel biosensor …