Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised …

A Papi, J Vestbo, L Fabbri, M Corradi, H Prunier… - The Lancet, 2018 - thelancet.com
… of triple therapy versus dual bronchodilation. In particular, no studies have directly compared
single-inhaler triple therapy with single-inhaler dual bronchodilator therapy for reducing …

Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease

DP Tashkin, GT Ferguson - Respiratory research, 2013 - Springer
… Long-acting bronchodilators are the mainstay of therapy due to their proven efficacy. GOLD
guidelines recommend combining long-acting bronchodilators with differing mechanisms of …

… salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group …

HAM Kerstjens, TB Casale, ER Bleecker… - The Lancet …, 2015 - thelancet.com
… in the tiotropium 5 μg group than in the 2·5 μg group, and the small … bronchodilator reversibility
between the treatment groups. Indeed, an association between increased bronchodilator

… triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group …

D Singh, A Papi, M Corradi, I Pavlišová, I Montagna… - The Lancet, 2016 - thelancet.com
… Few data are available for the efficacy of “triple therapy” with two long-acting bronchodilators
and an inhaled corticosteroid in chronic obstructive pulmonary disease (COPD). We …

… olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial

PMA Calverley, AR Anzueto, K Carter… - The Lancet …, 2018 - thelancet.com
… and the lack of a run-in period meant that we did not select individuals who could manage
without inhaled bronchodilator therapy. Finally, the observed exacerbation rate was close to …

… disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group …

JA Wedzicha, M Decramer, JH Ficker… - The lancet Respiratory …, 2013 - thelancet.com
… was that the potent bronchodilator effect of a fixed-… bronchodilator therapy, particularly in
terms of prevention of COPD exacerbations. We also expected that a greater bronchodilator

Nedocromil sodium and placebo in the treatment of bronchial asthma: a multicenter, double-blind, parallel-group comparison

J Greif, G Fink, Y Smorzik, M Topilsky, I Bruderman… - Chest, 1989 - Elsevier
… hours after taking oral or inhaled bronchodilator therapy. Three measurements were taken
… Patients were also asked to record the number of inhalations of bronchodilator aerosol used …

A randomized, parallel-group study to evaluate the efficacy of umeclidinium/vilanterol 62.5/25 μg on health-related quality of life in patients with COPD

TM Siler, AC Donald, D O'Dell, A Church… - International Journal of …, 2016 - Taylor & Francis
… monotherapy, so comparisons with other active therapies can only … therapy, there remains
limited data available in less symptomatic patient subgroups with dual bronchodilator therapy. …

… inhaler extrafine triple therapy versus long-acting muscarinic antagonist therapy for chronic obstructive pulmonary disease (TRINITY): a double-blind, parallel group …

J Vestbo, A Papi, M Corradi, V Blazhko, I Montagna… - The Lancet, 2017 - thelancet.com
… Limited data are available for the efficacy of triple therapy with two long-acting bronchodilators
and an inhaled corticosteroid in chronic obstructive pulmonary disease (COPD). We …

Results of a multicenter study of nebulized inhalant bronchodilator solutions

DP Tashkin, E Bleecker, S Braun, S Campbell… - The American journal of …, 1996 - Elsevier
… The study was a randomized, double-blind, 85-day, parallelgroup, eight-center … bronchodilator
agents to patients with COPD. 1 Beneficial effects of maintenance bronchodilator therapy