c-Jun, at the crossroad of the signaling network

Q Meng, Y Xia - Protein & cell, 2011 - academic.oup.com
… , c-Jun remains at the center stage of a molecular network with … overview of studies on c-Jun
regulation and function, and … the complexity of c-Jun crosstalking with signaling pathways. …

The multifaceted output of c-Jun biological activity: focus at the junction of CD8 T cell activation and exhaustion

AG Papavassiliou, AM Musti - Cells, 2020 - mdpi.com
c-Jun/AP-1 transcription factor in different types of mammal cells, this review focus on the
current understanding of c-Jun/… C-Jun and/or AP-1 mediate signaling pathways that ultimately …

MAPK/c-Jun signaling pathway contributes to the upregulation of the anti-apoptotic proteins Bcl-2 and Bcl-xL induced by Epstein-Barr virus-encoded BARF1 in gastric …

Y Zhang, M Xu, X Zhang, F Chu… - Oncology …, 2018 - spandidos-publications.com
… Therefore, the present study hypothesized that JNK1/2/3‑, p38‑ and ERK1/2-MAPK/c-Jun
cascade signaling pathways may contribute to the upregulation of the expression of the anti‑…

Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases

J Liu, A Lin - Oncogene, 2007 - nature.com
signaling pathways decides the function of the cell signaling circuitry. Understanding the
wiring of the cell signaling circuitry may hold the key for cell signaling-… In addition to c-Jun, JNK …

C-Jun NH2-terminal kinase and p38 inhibition suppresses prostaglandin E2-stimulated aromatase and estrogen receptor levels in human endometriosis

C Zeng, J Xu, Y Zhou, H Yang, Y Zhou… - The Journal of Clinical …, 2015 - academic.oup.com
… The role of MAPK signaling pathways has been investigated in many diseases (33, 34). …
activates p38 and JNK signaling pathways, stimulating binding of c-Jun and ATF2 to aromatase …

Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism

KE Shapira, M Ehrlich, YI Henis - Molecular Biology of the Cell, 2018 - Am Soc Cell Biol
… of total JNK/c-Jun and Smad2/3 provides the basis for the effects of cholesterol depletion on
these downstream components of TGF-β signaling pathways. Several potential mechanisms …

[HTML][HTML] Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation

J Xie, S Zhang, Y Hu, D Li, J Cui, J Xue, G Zhang… - … et Biophysica Acta (BBA …, 2014 - Elsevier
… requires activation of multiple signaling pathways. These … c-jun phosphorylation, we suggest
that the level of total c-jun … of IAV infection, while c-jun activation (phosphorylation) may exert …

PKCζ at the crossroad of NF-κB and Jak1/Stat6 signaling pathways

J Moscat, P Rennert, MT Diaz-Meco - Cell Death & Differentiation, 2006 - nature.com
… kinase (ERK)5, which leads to c-Jun regulation and cell growth in response to certain …
the IL-1, NGF, and LPS signaling pathways controlling NF-κB through still not totally clarified …

[HTML][HTML] c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis

J Yang, J Wang, Y Zhang, W Huang, S Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
… that c-Jun interacts with multiple signaling pathways to amplify or integrate the effects of
different signaling pathways in … In addition, despite few human cancers having causative c-Jun

c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-β1 and 4-hydroxynonenal in colon mucosa

F Biasi, B Vizio, C Mascia, E Gaia, N Zarkovic… - Free Radical Biology …, 2006 - Elsevier
signal pathways induced, respectively, by TGF-β1 and by HNE, we investigated the cross talk
between these signal transduction pathways … represent a crucial crossroad for helping the …