[HTML][HTML] cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids
The effect of n-6 polyunsaturated fatty acids (n-6 PUFAs) on adipogenesis and obesity is
controversial. Using in vitro cell culture models, we show that n-6 PUFAs was pro-
adipogenic under conditions with base-line levels of cAMP, but anti-adipogenic when the
levels of cAMP were elevated. The anti-adipogenic action of n-6 PUFAs was dependent on a
cAMP-dependent protein kinase-mediated induction of cyclooxygenase expression and
activity. We show that n-6 PUFAs were pro-adipogenic when combined with a high …
controversial. Using in vitro cell culture models, we show that n-6 PUFAs was pro-
adipogenic under conditions with base-line levels of cAMP, but anti-adipogenic when the
levels of cAMP were elevated. The anti-adipogenic action of n-6 PUFAs was dependent on a
cAMP-dependent protein kinase-mediated induction of cyclooxygenase expression and
activity. We show that n-6 PUFAs were pro-adipogenic when combined with a high …
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