… Based on the overlap of significant gene expression changes with established HAND2 DNA
… putative HAND2-dependent endocardial transcriptional enhancers. We selected five genes …

… These observations indicate that in zebrafish, hand2 regulates cardiac chamber-specific
gene expression and has a more general role in the early morphogenesis and differentiation of …

… be critical for cardiac morphogenesis including, trabeculation… heart and each cell lineage
relies on a finely tuned gene … Hand1 and Hand2 play key roles within the gene regulatory …

… HAND2 target genes, we determined which of the genes with known alterations in their
expression are associated with HAND2 … of these genes are associated with at least one HAND2 …

… myocardial cells and defects in myocardial gene expression [ … few myocardial precursors
that are present in hand2 mutants … polarized myocardial epithelia despite a similar reduction in …

… Hand2 plays critical roles during cardiac morphogenesis via expression and function within
myocardial, … Therefore, we examined Notch pathway gene expression. We first analyzed …

… component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is
expressed … Here, we provide the first genetic link between Hand2 and a downstream effector …

… utilizing a variety of unique Cre-driver mouse lines, we have revealed some tissue-specific
roles of the Hand2 gene during the development of early cardiac progenitors. More …

… Here, we found that the other Hand gene, Hand2, regulated expansion, trabeculation, and
… of Hand2 during cardiac morphogenesis, we created transgenic mice expressing Hand2 …

… in the control of cardiac morphogenesis and ventricular gene expression. These findings …
in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription. …