The role of p38 MAP kinase in cancer cell apoptosis

M Lenassi, A Plemenitaš - Radiology and Oncology, 2006 - radioloncol.com
… Recently, it was observed that retinoids, cisplantin and also other chemoterapeutic agents
initiate cancer cell apoptosis through the activation of p38 MAP kinase. This finding connects …

p38 MAPK in development and cancer

C Bradham, DR McClay - Cell cycle, 2006 - Taylor & Francis
… For example, p38 was shown to induce apoptosis in some cells, but prevent apoptosis in
others. … such as vinblastine, vincristine and taxol induce tumor cell apoptosis that is inhibited by …

p38 MAP kinase: a convergence point in cancer therapy

JM Olson, AR Hallahan - Trends in molecular medicine, 2004 - cell.com
… upstream of p38 MAPK. Here, we review p38-MAPK-mediated tumor cell apoptosis and …
However, it is difficult to assess the effect of p38 MAPK or p38 MAPK inhibitors on apoptosis

p38 MAP kinase regulates stem cell apoptosis in human hematopoietic failure

L Zhou, J Opalinska, A Verma - Cell cycle, 2007 - Taylor & Francis
p38 MAPK is overactivated in myelodysplasia bone marrows and regulates hematopoi‑ etic
stem cell apoptosis… Our results demonstrate that p38 MAPK is activated in bone marrow cells

Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis

J Saldeen, JC Lee, N Welsh - Biochemical pharmacology, 2001 - Elsevier
… IFN-γ increased both apoptosis and necrosis in rat islet cells. … , partially prevented
cytokine-induced apoptosis, an effect that was … -induced p38 activation participates in β-cell

Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy

MJ Rane, YE Song, S Jin, MT Barati… - American Journal …, 2010 - journals.physiology.org
… contributes to p38 MAPK-mediated RPTC apoptosis, fibrosis, … 1) whether Akt/p38 MAPK
expression/phosphorylation is … /p38 MAPK expression/phosphorylation and RPTC apoptosis are …

p38 MAPK mediates γ-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3 …

P Kumar, AI Miller, PJ Polverini - Journal of Biological Chemistry, 2004 - ASBMB
… protected from γ-irradiation-induced apoptosis predominantly through the PI3K/Akt … cell
apoptosis predominantly via the activation of p38 MAPK, and VEGF protects endothelial cells

Tumor necrosis factor alpha induces neural stem cell apoptosis through activating p38 MAPK pathway

N Chen, F Wei, L Wang, S Cui, Y Wan, S Liu - Neurochemical research, 2016 - Springer
… underlying TNF-α-induced apoptosis in NSCs. Our research demonstrates the role of p38
MAPK as a novel apoptotic signal during TNF-α-induced apoptosis in NSCs. Moreover, our …

Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK

Y Zhou, Q Wang, BM Evers, DH Chung - Biochemical and biophysical …, 2006 - Elsevier
… types, we sought to determine the exact role of p38 MAPK in the H 2 O 2 -… cell (RIE-1)
apoptosis. We show that H 2 O 2 induces apoptosis in RIE-1 cells with activation of p38 MAPK. …

p38 MAPK mediates renal tubular cell TNF-α production and TNF-α-dependent apoptosis during simulated ischemia

KK Meldrum, DR Meldrum, KL Hile… - … of Physiology-Cell …, 2001 - journals.physiology.org
… As we develop a greater understanding of mediators of ischemia-induced renal cell
apoptosis, such as p38 MAP kinase, effective therapeutic strategies that limit or prevent ischemia-…