Hierarchy, tolerance, and dominance in the antitumor T-cell response

NP Restifo - Journal of Immunotherapy, 2001 - journals.lww.com
… to the SV40 large T antigen could be classified in a hierarchical system (10) . … as
immunodominant (designated IV), no immune responses were observed, although immune …

[HTML][HTML] Immunodominance hierarchies and gender bias in direct TCD8-cell alloreactivity

NA Mifsud, AW Purcell, W Chen, R Holdsworth… - American journal of …, 2008 - Elsevier
… T-cell alloreactivity. We demonstrate remarkably reproducible patterns of immunodominance
in … reflecting alloantigenic competition in responder cell responses. In strong alloresponses, …

Contemporary analysis of MHC-related immunodominance hierarchies in the CD8+ T cell response to influenza A viruses

GT Belz, PG Stevenson, PC Doherty - The Journal of Immunology, 2000 - journals.aai.org
… The overall conclusion was that we were seeing some sort of immunodominance hierarchy,
where a concurrent H2K k -restricted response functioned to minimize that associated with …

[HTML][HTML] Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses

JW Yewdell - Immunity, 2006 - cell.com
… This appears to be the first published observation relating the route of viral immunization
to the immunodominance hierarchy, which is surprising, given that this is potentially of great …

Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral Cd8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens

W Chen, CC Norbury, Y Cho, JW Yewdell… - The Journal of …, 2001 - rupress.org
… skew the true frequencies of responding cells. With the improved … Thus, understanding the
rules of determinant hierarchy … the immunodominance hierarchy in the T CD8+ response to …

A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

NL La Gruta, K Kedzierska, K Pang… - Proceedings of the …, 2006 - National Acad Sciences
… in a normal immune response is far from clear. An intriguing immunodominance hierarchy
is found for the CD8 + T cell responses to the nucleoprotein NP 366 and acid polymerase PA …

… in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination

W Chen, K Pang, KA Masterman… - The Journal of …, 2004 - journals.aai.org
… X31-infected allogeneic cells results in a similar immunodominance hierarchy as boosting
with … virus and infected cells to limit activation to strain specific NP 366–374 -specific T CD8 + . …

Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination

W Kastenmuller, G Gasteiger, JH Gronau… - The Journal of …, 2007 - rupress.org
… of pathogen-specific determinants, T cell responses to viral infections have been found to …
T cell responses against different epitopes can be arranged in an immunodominance hierarchy

Factors influencing immunodominance hierarchies in TCD8+-mediated antiviral responses

K Irvine, J Bennink - Expert Review of Clinical Immunology, 2006 - Taylor & Francis
… with a structured hierarchy. These immunodominance hierarchies result from a complex
combination of factors. Major roles are played by peptide binding affinity, T-cell repertoire, and …

… Deficient in Perforin, CD4+ T Cells, or CD28-Mediated Signaling Maintain the Typical Immunodominance Hierarchies of CD8+ T-Cell Responses to Influenza Virus

W Chen, JR Bennink, PA Morton, JW Yewdell - Journal of virology, 2002 - Am Soc Microbiol
immunodominance hierarchies, we studied influenza virus specific-T CD8+ responses in
mice … an essential role in establishing the immunodominance hierarchy in T CD8+ responses. …