… cell survival, we performed apoptosis assays. U2-OS cells were cotransfected with Kit and
… ) expression construct to allow the detection of transfected cells. After 12 h serum starvation, …

… In this review we address the importance of c-Kit signalling within the … cell survival and
function. We also discuss the impact of c-Kit signalling in pancreatic disease and the use of c-Kit …

… roles in signal transduction of Kit/KL-mediated proliferation, survival and cell adhesion, we
… Kit receptor variants and mutant Kit receptors with phenylalanine substitutions of the Kit …

… mast cell development, survival, and function. SCF can promote mast cell survival by sup
pressing apoptosis, induce mast cell … induce SCFR-dependent mast cell mediator re lease, and …

… The receptor tyrosine kinase c-Kit and its ligand Stem Cell … cell survival, proliferation,
differentiation, adhesion and functional activation. It is of particular importance in the mast cell and …

… for mast cell survival that acts by promoting KIT receptor signaling. This receptor-upon-ligand
recognition initiates signals that are critical for mast cell growth, development, and survival (…

… of c-kit receptor found in tumor mast cell lines. As the murine C-kit receptor can be recognized
by murine and rat SCF but not by human SCF, a human embryonic kidney cell line (2939 …

… balance between cell death and cell survival during liver diseases. The strict regulation of
apoptotic cell death … Apoptotic cell death can be initiated by activation of death receptors on the …

… soluble isoform because it is more difficult to perform co-culture experiments with the
membrane-anchored SCF in one cell type stimulating the Kit receptor in another cell type. …

… of c-Kit lacks both mucosal and connective tissue-type MCs. In bone marrow-derived mast
cells (BMMCs), the 787F mutation does not affect SCF binding and c-Kit receptor shedding, …