[HTML][HTML] Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment
… measures and reduce the burden of cancer, we reflect here on the role of carcinogenicity …
advances in carcinogenicity assessment and their potential to help the fight against cancer. …
advances in carcinogenicity assessment and their potential to help the fight against cancer. …
Assessment of human cancer risk: challenges for alternative approaches
GS Omenn - Toxicologic pathology, 2001 - journals.sagepub.com
… Testing aims to develop and apply new methods for assessment of potential carcinogenic
risk to humans from various chemicals. The Workshop represents a major cooperative scientifi …
risk to humans from various chemicals. The Workshop represents a major cooperative scientifi …
The use of genetically modified mice in cancer risk assessment: challenges and limitations
DA Eastmond, SV Vulimiri, JE French… - Critical reviews in …, 2013 - Taylor & Francis
… conventional rodent cancer bioassay and for assessing human health … cancer bioassays
with GM mice for assessing the potential health risks associated with exposure to carcinogenic …
with GM mice for assessing the potential health risks associated with exposure to carcinogenic …
In silico approaches in carcinogenicity hazard assessment: current status and future needs
RR Tice, A Bassan, A Amberg, LT Anger… - Computational …, 2021 - Elsevier
… carcinogenicity models to be developed, especially ones that are more directly applicable to
predicting the risk for cancer in … The use of these KCs to identify carcinogens is challenging …
predicting the risk for cancer in … The use of these KCs to identify carcinogens is challenging …
Advancing chemical carcinogenicity prediction modeling: opportunities and challenges
… Carcinogenicity assessment of any compound is a laborious and expensive exercise
with … challenges concerning the inadequacy of available experimentally validated (non)carcinogen …
with … challenges concerning the inadequacy of available experimentally validated (non)carcinogen …
Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a toxicology forum state-of-the-science workshop
SP Felter, VS Bhat, PA Botham… - Critical Reviews in …, 2021 - Taylor & Francis
… The workshop sessions addressed key challenges in carcinogenicity assessment related
to … and assessing mechanisms and MoAs relevant to human cancers. At present, full …
to … and assessing mechanisms and MoAs relevant to human cancers. At present, full …
Predicting the carcinogenicity of chemicals with alternative approaches: recent advances
R Benigni - Expert Opinion on Drug Metabolism & Toxicology, 2014 - Taylor & Francis
… , and then the longer or more challenging tests are used only on … higher the number of
putatively cancer hazard processes a … in vitro methods for assessing the carcinogenic potential of …
putatively cancer hazard processes a … in vitro methods for assessing the carcinogenic potential of …
[HTML][HTML] Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop
… of rodent bioassay data to predicting human cancer risks have emerged, with notable
challenges in both anticipating the potential human cancer target organs and in quantitative risk …
challenges in both anticipating the potential human cancer target organs and in quantitative risk …
A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies
CL Yauk, AH Harrill, H Ellinger-Ziegelbauer… - Regulatory Toxicology …, 2020 - Elsevier
… Further discussion of opportunities to advance the field of toxicogenomics and implement
near-term tools/solutions for contemporary challenges in cancer risk assessment follows below…
near-term tools/solutions for contemporary challenges in cancer risk assessment follows below…
Uncertainties of testing methods: What do we (want to) know about carcinogenicity?
M Paparella, A Colacci, MN Jacobs - ALTEX-Alternatives to animal …, 2017 - altex.org
… in vitro approaches to testing and assessment. The format is … be conceptually similar to the
challenge of integrating relevant in … of rodent forestomach tumors in cancer risk assessment. …
challenge of integrating relevant in … of rodent forestomach tumors in cancer risk assessment. …