… functions; a process known as the chaperokine activity of Hsp70. This review will highlight
… Hsp70 initiates the host's immune response. Keywords: Chaperokine, exosomes, exercise, …

… role by initiating immune responses designed to fend … immune responses and suggest the
possible biological significance of circulating Hsp to the host. Keywords: Cancer, chaperokine, …

… The released extracellular HSP70 interacts with cells of the immune system and exerts
immunoregulatory effects - known as the chaperokine activity of HSP70. The chaperokine activity …

… of the mechanism by which the chaperokine activity of Hsp72 is transduced, addresses its
… long lasting immune response. eHsp72 induces a plethora of immune responses and the …

… is MyD88-independent, suggesting an alternative pathway by which extracellular HSPA1A
stimulates cells of the immune system. Our working hypothesis is summarized in Fig. 1.2. …

… acts to stimulate the immune system. The chaperokine activity of eHsp72 would constitute
… In this chapter we assessed chaperokine activities of HSP70 family especially Hsp72. Also, …

… cells of the immune system. Independent studies by Vabulas et al.(2002) confirmed these
findings, thereby classifying extracellular HSPA1A as an intracellular natural adjuvant. …

… cells of the immune system. Independent studies by Vabulas et al. (2002) confirmed
these findings, thereby classifying extracellular HSPA1A as an intracellular natural adjuvant. …

… Because they initiate adaptive immune responses and determine tolerance, DCs are ideally
… the important role of chaperokines in the adoptive immune response. To finally confirm the …

… NF-κB activity and subsequent … immune response to HSP70-peptide preparations. Thus,
during the first few hours of the immune response, we show that cells of the innate immune …