… is the main proteolytic arm of the ubiquitin pathway. The … by ubiquitin-Cterminal specific
proteases (UBPs; isopeptidases). … from Lys residues of end proteolytic products, to disassemble …

… Signalling proteolytic pathways and crosstalk with protein … pathway stimulates protein
synthesis and myofiber growth and inhibits FoxO3 nuclear import, resulting in low proteolysis. The …

… proteases in the pathogenesis of IBD. We highlight and discuss studies demonstrating
that proteases and protease … luminal protease activity and activation of protease receptors, …

… The proteolysis of von Willebrand factor (VWF) by the … increased proteolysis and some of
which compromise proteolysis. … current knowledge of VWF proteolysis by ADAMTS13, and a …

… This review will consider our current understanding of the proteolytic mechanisms in Aβ …
proteases as therapeutic targets. Recent developments include the identification and clinical …

… Specifically, the molecular mechanisms by which the HIV protease inhibitor class of drugs
may … This article outlines select, known mechanisms for a direct clinical impact of the protease …

… , and clinical implications of cathepsins in the extracellular space. … protease family called
lysosomal cysteine proteases, is an essential enzyme in the process of intracellular proteolysis. …

… targeting cathepsins as part of the proteolytic pathway. Several experimental studies have …
signaling pathway and inflammation and NAPDH oxidase/extracellular protease activation in …

… Intracellular proteases, mainly caspases and cathepsins, modulate lysosome activity …
pathways. Herein, we discuss the current knowledge on the multidimensional impact of proteases …

… an impairment of the proteolytic pathways is one of the hallmarks of α-syn-induced toxicity.
Therefore, modulation of the proteolytic molecular pathways that are deregulated appears as …